Abstract: The effects of combination application of potassium (K) and lead (Pb) at different concentrations on Pb accumulation in different organs of Corydalis yanhusuo and its growth were investigated by using a pot experiment. The accumulation of Pb in C. yanhusuo plant and its above- and under-ground biomass were measured. Compared with the soil without the application of Pb and K, the biomass of above- and under-ground plant was increased by 16.26% and 13.44% in the soil with low Pb background, and by 10.26% and 7.40% in the soil with high Pb background, respectively. While the K application alleviated the Pb biological toxicity and led to the growth of C. yanhusuo normally. Compared with the treatment without K application, the biomass of above- and under-ground plants in the medium K treatment was increased by 18.67% and 35.97% under the low Pb background of soil, respectively, and was increased by 29.24% and 46.78% under the high Pb background of soil, respectively. At the same time, the accumulation of Pb in different parts of C. yanhusuo showed a significant difference between the above- and under-ground plants. The Pb accumulation in under-ground plant was decreased with time, while that in above-ground plant was increased first and then decreased with time. Compared with the treatment without K application, the medium K treatment decreased the Pb contents of above- and under-ground plants by 44.08% and 53.37% under the low Pb background of soil, respectively, and by 28.26% and 14.07% under the high Pb background of soil, respectively. Therefore, in the standardized planting C. yanhusuo, it is better to choose soil with low Pb content as the planting areas, while increasing 200 mg kg⁻¹ K-fertilizer could alleviate oxidative damage of heavy metal to medicinal plants and improve the yield.