Abstract: With the increasingly serious problem of soil salinization worldwide, it has become particularly important to enhance plant tolerance to highly saline environments and to use cost-effective and adaptive methods for the restoration and improvement of saline soils. This paper outlines the interaction mechanism between saline plants and inter-root soil microorganisms under saline and alkaline stress, demonstrating a mutually beneficial symbiotic relationship between the two entities. On one hand, plants grown in saline soil can enhance the growth of soil microorganisms between their roots, utilizing their inter-root activities for the selection of beneficial bacteria to promote their growth and colonize the inter-roots. On the other hand, soil microorganisms stimulate osmoregulation, the release of endogenous hormones, and antioxidant defenses to promote the normal growth and development of saline plants under saline stress. This helps to enhance their adaptation to extremely hypersaline habitats. The future research direction will focus on enhancing the understanding of the interaction mechanism between saline plants and inter-root soil microorganisms at the molecular level. In addition, emphasis will be placed on the practical application of inter-root biotrophic bacteria extracted from saline plants inter-roots to crop cultivation and field practice. We aim to offer a comprehensive understanding of the salt tolerance mechanisms of saline plants and their interactions with inter-root soil microorganisms. We also hope to propose innovative solutions for enhancing plant resilience, and restoring and improving saline soils